| Reference Number | Title | Date |
| RCPI/8/1/3/8 | Material donated to Library | 1960-c.1977 |
| RCPI/4/3/6/7 | Memorandum | May 1871 |
| RCPI/8/1/5/4 | Dr James Little Bequest | 16 July 1959 - 4 November 1959 |
| RCPI/10/1/2 | Draft letter to the General Medical Council | 12 February 1870 |
| TPCK/6/5/15 | Unveiling of Plaque to James Little | 17 January 1922 |
| DBC/10/21 | James Little | [late nineteenth - early twentieth century] |
| TPCK/6/5/10 | Diary of James Little | 1847-1860 |
| VM/1/2/L/16a | Photograph of James Little | c.1900s |
| VM/1/2/L/16 | Photographs of James Little | c.1900s |
| TPCK/6/7/7/2 | Photograph Album | 1885-1886 |
| HI/1882-2 | Portrait of Alfred Hudson | 1850-1899 |
| HI/1917-3 | Portrait of James Little | 1875-1925 |
| VM/1/1/4 | Roll of Presidents Vol II - 1801-1914 | 1915 |
| AHC/1/3 | Medical Board Bank Account Books | 1869-1945 |
| RCPI/2/3/2/13/225 | Letter to James Little, 6 Glendower Place, South Kensington | 14 April 1917 |
| RCPI/2/3/1/59/Upsilon1a | Letter from James Little, New University Club, London | 11 January 1917 |
| RCPI/2/3/1/59/Upsilon1b | Letter from R H Beauchamp & Orr, Solicitors, 5 Foster Place, Dublin | 17 January 1917 |
| RCPI/2/3/1/59/Upsilon18 | Letter from James Little, 6 Glendower Place, South Kensington | [April 1917] |
| RCPI/2/3/1/59/Upsilon25 | Letter from James Little, New University Club, St James's Street, S.W | 20 April [1917] |
| RCPI/2/3/1/59/Upsilon46 | Letter from R H Beauchamp & Orr, Solicitors, 5 Foster Place, Dublin | 29 August 1917 |
| RCPI/2/3/1/59/Upsilon86 | Letter from the School of Physic, Trinity College, Dublin | 22 May 1918 |
| BMS/56 | Medical photograph scrapbook | [1901-1916] |
| VM/1/2/L/16b | Photograph of James Little | c.1900s |
| VM/1/2/L/16c | Photograph of James Little | c.1900s |
| VM/1/2/L/16d | Photograph of James Little | c.1900s |
| VM/1/2/L/16e | Photograph of James Little | c.1900s |
| VM/1/2/L/16f | Photograph of James Little | c.1900s |
| VM/1/2/L/16g | James Little | c.1900s |
| VM/1/2/L/16h | James Little | c.1900s |
| VM/1/2/L/16i | James Little | c.1900s |
| VM/1/2/L/16j | Photographs of James Little | c.1900s |
| HI/1964-1 | James Little Silver Two-Handled Cup | c.1750 |
| HI/1922-3 | Bronze Portrait Plaque of James Little | 1921 |